Composition
Trimethoprim
Sulphamethoxazole
Description
The combination of trimetoprim and sulpha-methoxazole acts synergistic and in many cases bactericidal against a large number of Gram-positive and Gram-negative bacteria, e.g. some Staphylococci, Streptococci, E. coli, Klebsiella spp., Salmonella spp., Proteus mirabilis, Pasteurella spp., Enterobacter aerogenes, Haemophilus influenza and Corynebacterium spp..There is hardly any activity against Pseudomonas aeruginosa, Proteus vulgaris and some other Staphylococci. After oral administration both components will be absorbed rapidly and almost completely from the gastro-intestinal tract.
Indications
SENTO TMPS Oral is indicated for infections caused by micro-organisms susceptible to trimethoprim and/or sulpha-methoxazole, like gastro-intestinal, respiratory or urogenital infections and general infections in calves, sheep, goats, pigs and poultry.
Contra-indications
- Do not administer to animals with serious liver and/or renal dysfunctions, hypersensitivity to sulphonamides.
- Do not use in layers producing eggs for human consumption.
- Do not administer to animals with diseases with decreased urine production (oliguria, anuria).
Side-Effects
Hypersensitivity reactions, cross-resistance to sulphonamides. Administration during two weeks or more may increase the risk for blood dyscrasias, folic acid deficiency and/or crystalluria.
Incompatibility with other drugs or substances
- Do not administer in combination with ionophore coccidiostatics because of the increased toxic action.
- Do not administer simultaneously with para-aminobenzoic acid or its esters (procaine, tetracaine) or with methenamine.
Dosage and administration
For oral administration, via drinking water.
Calves, sheep, goats : 5 ml per 40 kg bodyweight, once or twice a day, during 5 days. The solution must be diluted with water 1:5
Poultry and turkeys: 1 liter per 500 – 1000 liters of drinking water, during 4 – 5 days.
Withdrawal Period
Meat : 10 days
Storage
Store in a dry and dark place between 8°C and 25°C. in closed packing.
Package
500 ml , 1 liter PE-Pharma bottle